I would highly recommend Alpha to everyone. 5.0 Halleemah N. Los Angeles, CA. 2/13/2020. Repair a Concrete Foundation. Alpha Stuctural and their incredible team gets every star in the universe for this rating! From the initial assessment, pricing and invoicing, project work to completion - the team was top flight! Facebook. 4.7 stars from 14 reviews. “Alpha Structural, Inc. Thanks for being the best construction team around! Even Megatron can’t break through my wall! Autobots Roll Out!!!”. Tom DeSanto. (Producer on Transformers Dark of the Moon) “Alpha Structural was an answer to our prayers. In non-muscle cells, alpha-actinin is found along the actin filaments and in adhesion sites. In striated, cardiac and smooth muscle cells, it is localized at the Z-disk and analogous dense bodies, where it forms a lattice-like structure and stabilizes the muscle contractile apparatus. Besides binding to actin filaments alpha-actinin … Alpha Structural, Inc. Headquarters: 8334 Foothill Blvd. Sunland, CA 91040 Office: 1638 Colorado Blvd #201, Los Angeles, CA 90041 Orange County Office: 23031 E. La Palma Ave. Yorba Linda, CA 92887 If your property is showing signs of foundation problems and you are in need of a trusted foundation replacement service, then visit us at Alpha Structural or contact us at (323) 258-5482 to schedule an appointment. Concrete Slab Foundation Replacement With Alpha Structural. At Alpha Structural, professionalism is a way of life. Specialties: Providing structural and geotechnical repairs and upgrades with our signature design/build approach for over 30 years. We service single-family, multi-family, industrial and commercial properties. Established in 1988. * #1,758 on 2019 Inc. 5000 list * #29 Fastest Growing Private Company in L.A. - L.A. Business Journal * Angie's List Super Service Award (2009-2019) * Talk of the ... Only rat α-LA contains 17 additional C-terminal residues. α-LA is homologous in sequence to the lysozyme family, but it exhibits cell lytic activity about 10 −6 of the specific activity of hen egg white lysozyme [9]. X-ray crystallography has shown that the three-dimensional structure of α-LA is very similar to that of …Alpha Structural is the top hillside repair contractor in Los Angeles, offering slope repair and slope reinforcement. In Los Angeles and Orange Counties, many hillside homes were built in the 1950s and 1960s with deepened foundation systems that were deemed to be deep enough to withstand earthquakes and weather storms.Alpha Structural has been helping commercial property owners with a wide range of commercial services for more than two decades now – we are committed to delivering 100% quality work for all our clients. (323) 258-5482 Menu. Serving Los Angeles and Southern California for ... Alpha Structural is a foundation inspection and repair company with over 850 years of combined experience. Meet the staff of the most qualified and trusted structural inspectors in Los Angeles. Nov 17, 2021 · The AlphaFold Protein Structure Database (AlphaFold DB, https://alphafold.ebi.ac.uk) is an openly accessible, extensive database of high-accuracy protein-structure predictions. Powered by AlphaFold v2.0 of DeepMind, it has enabled an unprecedented expansion of the structural coverage of the known …The tertiary structure of a protein is a description of the way the whole chain (including the secondary structures) folds itself into its final 3-dimensional shape. This is often simplified into models like the following one for the enzyme dihydrofolate reductase. Enzymes are, of course, based on proteins.The high-pressure behavior of quartz has been the subject of extensive experimental studies. At ambient conditions, the stable polymorph of SiO 2 is the trigonal α-quartz structure (P3 2 21), composed of a corner-linked framework of SiO 4 tetrahedra. On the basis of the equilibrium phase diagram, SiO 2 adopts …Out with our Alpha Structural, Inc. #orangecounty team setting steel through the roof in Lake Forest. #crane #structuralsteel #steelconstruction… Liked by Nick KurtzAlpha Structural: A structural engineering and construction firm that has been providing structural repairs and upgrades to Southern California for over three decades.Expert Career Advice. Glassdoor gives you an inside look at what it's like to work at Alpha Structural, including salaries, reviews, office photos, and more. This is the Alpha …Alpha 2.0, standing at 29 meters (95 feet) tall in total, comprises a two-stage structure. Topping the rocket is the newly enlarged payload segment, made up of a 2-meter (6.6-foot) diameter carbon fiber composite payload fairing covering the payload storage area.Glucose, also known as dextrose is the most common simple sugar (monosaccharide). It has two isomeric structures, i.e. dextrose-(D) glucose and Lactose-(L) glucose. The dextrose-(D) glucose contains two further isomers, i.e. alpha (α) and beta (β) glucose. The key difference between alpha (α) and beta (β) glucose is the orientation of …Alpha Structural's foundation repair customer reviews. Find out why they say we're the #1 foundation repair contractor in Los Angeles. (323) 258-5482 Menu. Serving Los Angeles and Southern California for Foundation Repair Since 1993. Call …Alpha Structural specializes in the design / build of foundation repair, hillside repair and general structural rehabilitation. Alpha Structural has done thousands of inspections of residential properties, leading to every conceivable type of foundation and hillside repair project. keywords:N/A. N/A.Fig. 1: Cryo-EM structures of human α7 nicotinic receptor in different states. a – c Cryo-EM maps of human α7 in apo ( a ), EVP-bound ( b) and EVP/PNU-bound ( c) states. Chemical structures of ...ALPHA-SYNUCLEIN STRUCTURE. α-Syn is a small acidic protein with three domains namely N-terminal lipid-binding α-helix, amyloid-binding central domain (NAC), and C-terminal acidic tail. α-Syn can be present as an α-helix structure in association with phospholipids or an unfolded conformation in the cytosol, suggesting that it plays specific roles …In the rhGAA-NAC complex structure a NAC molecule, designated as NAC1, is located about 30 Å away from the active site, at the interface between the (β/α) 8 barrel and the distal β-sheet ...The α-helix is the most abundant secondary structure in proteins. We now have an excellent understanding of the rules for helix formation because of experimental studies of helices in isolated peptides and within proteins, examination of helices in crystal structures, computer modeling and simulations, and theoretical work.The high-pressure behavior of quartz has been the subject of extensive experimental studies. At ambient conditions, the stable polymorph of SiO 2 is the trigonal α-quartz structure (P3 2 21), composed of a corner-linked framework of SiO 4 tetrahedra. On the basis of the equilibrium phase diagram, SiO 2 adopts …2. Secondary Structure . Secondary Structure refers to the coiling or folding of a polypeptide chain that gives the protein its 3-D shape.There are two types of secondary structures observed in proteins. One type is the alpha (α) helix structure.This structure resembles a coiled spring and is secured by hydrogen …α-Mangostin has been reported to possess a broad range of pharmacological effects including potent cholinesterase inhibition, but the development of α-mangostin as a potential lead compound is impeded by its toxicity. The present study investigated the impact of simple structural modification of α-m …The tertiary structure of a protein is a description of the way the whole chain (including the secondary structures) folds itself into its final 3-dimensional shape. This is often simplified into models like the following one for the enzyme dihydrofolate reductase. Enzymes are, of course, based on proteins. Alpha Structural, Inc. Headquarters: 8334 Foothill Blvd. Sunland, CA 91040 Office: 1638 Colorado Blvd #201, Los Angeles, CA 90041 Orange County Office: 23031 E. La ... Specialties: Providing structural and geotechnical repairs and upgrades with our signature design/build approach for over 30 years. We service single-family, multi-family, industrial and commercial properties. Established in 1988. * #1,758 on 2019 Inc. 5000 list * #29 Fastest Growing Private Company in L.A. - L.A. Business Journal * Angie's List Super Service Award (2009-2019) * Talk of the ... Alpha Structural offers multiple solutions to preserve and protect historic structures. From sister foundations to brick foundation repair and stilt home reinforcement, our engineering-approved specialists can diagnose the fundamental issues your historic foundation faces and come up with solutions that will preserve the culture and history of ... Call us today to schedule an inspection or request an estimate. (323) 258-5482. Request an Assessment or Estimate ». The following list represents just some of the types of foundation repair we specialize in: Basement Expansion. Basement Waterproofing. Brick Foundation Repair. Caissons. Concrete Foundation Repair. Alpha Structural, Inc. Headquarters: 8334 Foothill Blvd. Sunland, CA 91040 Office: 1638 Colorado Blvd #201, Los Angeles, CA 90041 Orange County Office: 23031 E. La Palma Ave. Yorba Linda, CA 92887 The crystalline lattice structure of the α-chitin was found to be the orthorhombic space group P2 1 2 1 2 1 with unit cell dimensions a = 4.74 Å, b = 18.86 Å and c (fibre axis) = 10.32 Å , figure 2c. β-Chitin is mostly obtained from marine diatoms , molluscs and the peritrophic matrix in insects and the polymer chains …Alpha hydroxycarboxylic acid. Alpha hydroxy carboxylic acids, or α-hydroxy carboxylic acids ( AHAs ), are a group of carboxylic acids featuring a hydroxy group located one carbon atom away from the acid group. This structural aspect distinguishes them from beta hydroxy acids, where the functional groups are …In non-muscle cells, alpha-actinin is found along the actin filaments and in adhesion sites. In striated, cardiac and smooth muscle cells, it is localized at the Z-disk and analogous dense bodies, where it forms a lattice-like structure and stabilizes the muscle contractile apparatus. Besides binding to actin filaments alpha-actinin …Alpha Structural has been helping commercial property owners with a wide range of commercial services for more than two decades now – we are committed to delivering 100% quality work for all our clients. (323) 258-5482 Menu. Serving Los Angeles and Southern California for ...Why Structural Armor Composite Fiber Reinforced Building Materials? State-of-the-Art in Non-Corrosive Pool Walls . Fully Customizable in Shape and Size. Any sunledge, ... combined with experienced and seasoned leadership give the Only Alpha Pool Products brand the leading edge in manufacturing construction …Specialties: Providing structural & hillside repairs with our signature design to build approach for over 25 years. We service single-family, multi-family, industrial and commercial properties. Established in 1988. * #1,758 on 2019 Inc. 5000 list * #29 Fastest Growing Private Company in L.A. - L.A. Business Journal * Angie's List …Structural Contradiction by Government Alpha, released 25 February 2019 1. I. Refractive 2. II. Dissolution 3. III. Liquefaction 4. IV. Vaporizable 5. V. Live Relay Collapse at Bushbash 6. VI. Live Relay Collapse at Soup After getting the pleasure of witnessing Yasutoshi play live in studio at KFJC, and then at the …The first two are simple carboxylic acids, and the third is an amino alcohol. All three compounds are soluble in organic solvents (e.g. ether) and have relatively low melting points. The carboxylic acids have pK a 's near 4.5, and the conjugate acid of the amine has a pK a of 10. The simple amino acid alanine is the last entry. Specialties: Providing structural and geotechnical repairs and upgrades with our signature design/build approach for over 30 years. We service single-family, multi-family, industrial and commercial properties. Established in 1988. * #1,758 on 2019 Inc. 5000 list * #29 Fastest Growing Private Company in L.A. - L.A. Business Journal * Angie's List Super Service Award (2009-2019) * Talk of the ... Schedule an engineering inspection to troubleshoot the issue. If your structure has cracked walls or a sagging roof, call on a highly trained structural engineer at Alpha Omega to check it out. We’ll respond quickly to evaluate the structural integrity of your home. During our engineering inspection, we’ll look at every part of your ...The ER α DBD : ERE structures have been studied extensively by several biophysical techniques [13, 23, 55, 58]. Three-dimensional structure of the ER α has been solved using nuclear magnetic resonance as well as X-ray crystallographic techniques both alone and in complex with DNA (Figure 1(b)) [13, …The toxicokinetics of alpha-pinene (a-pinene) were studied in humans.The study group consisted of eight healthy males, average age 31 years. They were exposed to 0, 10, 225, or 450 mg/cu m (+)-alpha-pinene or 450 mg/cu m (-)-alpha-pinene for 2 hr in an inhalation chamber. During exposure they exercised on a cycle … Charlie Rosenkranz is Alpha Structural, Inc.’s Vice President of Development. Rosenkranz brings over 17 years of experience in custom home building, hillside construction, caissons and grade beam construction, remodeling and foundation replacements to the Alpha Structural team. The crystalline lattice structure of the α-chitin was found to be the orthorhombic space group P2 1 2 1 2 1 with unit cell dimensions a = 4.74 Å, b = 18.86 Å and c (fibre axis) = 10.32 Å , figure 2c. β-Chitin is mostly obtained from marine diatoms , molluscs and the peritrophic matrix in insects and the polymer chains …Meet the team of qualified foundation repair staff at Alpha Structural, Inc., serving all of Southern California. Learn about their experience, skills and expertise in foundation repair and stabilization.Protein secondary structure is the local spatial conformation of the polypeptide backbone excluding the side chains. [1] The two most common secondary structural elements are alpha helices and beta sheets, though beta turns and omega loops occur as well. Secondary structure elements typically spontaneously form as an intermediate before the ...Feb 5, 2019 · The N-terminal transactivation domain (NTD) of estrogen receptor alpha, a well-known member of the family of intrinsically disordered proteins, mediates the receptor's transactivation function. However, an accurate molecular dissection of NTD's structure-function relationships remains elusive. Here, we … Who is Alpha Structural. Alpha Structural offers design and build structural repair services. It specializes in foundation repairs, structural repairs & upgrades, hillside repairs & earthquake retrofitting. The company was founded in 1993 and is based in Los Angeles, California. Read more. Alpha Structural's Social Media Jan 18, 2021 · Structural differences between the Form I and Form II filaments. The respective assemblies of Form I and Form II epitomized an unusual packing motif, recently designated as a cross-α structure 36 ... Alpha Structural, Inc. Headquarters: 8334 Foothill Blvd. Sunland, CA 91040 Office: 1638 Colorado Blvd #201, Los Angeles, CA 90041 Orange County Office: 23031 E. La ... Jul 8, 2021 · Pathogenic mycobacteria such as Mycobacterium tuberculosis, the causative agent of tuberculosis, are surrounded by a noncovalently bound capsule, whose major carbohydrate constituent is a glycogen-like alpha-glucan. In the present study we compared the structures of the extracellular polysaccharide …To solve the structure, we formed the α 1A AR complex with Nb29 and obtained the initial cryo-EM structure at 4 Å resolution, and found that Nb29 binds to the extracellular region of the α 1A ...For over 30 years now, Alpha Structural, Inc. has developed a powerful reputation as the #1 Foundation Services, Landslide repair and Earthquake Retrofitting Contractor in the …Call us today to schedule an inspection or request an estimate. (323) 258-5482. Request an Assessment or Estimate ». The following list represents just some of the types of foundation repair we specialize in: Basement Expansion. Basement Waterproofing. Brick Foundation Repair. Caissons. Concrete Foundation Repair. The Structural Assessor in Alpha Structural, Inc. is the one that will assess the property and recommend any repairs needed. Here at Alpha the Structural Assessor is senior to our engineering department in that they are the one to assess a property, design the solution and work out the proper budget for that repair. Out with our Alpha Structural, Inc. #orangecounty team setting steel through the roof in Lake Forest. #crane #structuralsteel #steelconstruction… Liked by Nick KurtzThe Lewy fold is formed by residues 31–100 of α-synuclein, which arrange as nine β-strands (β1–9) in a three-layered structure (Fig. 2 ). The first two layers are corrugated, with the first ...In non-muscle cells, alpha-actinin is found along the actin filaments and in adhesion sites. In striated, cardiac and smooth muscle cells, it is localized at the Z-disk and analogous dense bodies, where it forms a lattice-like structure and stabilizes the muscle contractile apparatus. Besides binding to actin filaments alpha-actinin …Top 10 Best Alpha Structural in Los Angeles, CA - September 2023 - Yelp - Alpha Structural, Alpha Structural, Inc. Orange County, The Foundation Works, White Castle Construction, LA Private Eyes Geotechnical Engineers, Pacific Outdoor Living, Omega Structural, Avalin Seismic Construction Company, Yetter Inspection …Alpha Structural is a design/build firm that specializes in foundation repairs, hillside repairs and structural retrofits for residential, multi-family and commercial properties in Los …Specialties: Providing structural & hillside repairs with our signature design to build approach for over 25 years. We service single-family, multi-family, industrial and commercial properties. Established in 1988. * #1,758 on 2019 Inc. 5000 list * #29 Fastest Growing Private Company in L.A. - L.A. Business Journal * Angie's List …AlphaFold is an AI system developed by Google DeepMind that predicts a protein’s 3D structure from its amino acid sequence. It regularly achieves accuracy competitive with …Alpha Structural, Inc. Headquarters: 8334 Foothill Blvd. Sunland, CA 91040 Office: 1638 Colorado Blvd #201, Los Angeles, CA 90041 Orange County Office: 23031 E. La Palma Ave. Yorba Linda, CA 92887 Alpha Structural, Inc. Headquarters: 8334 Foothill Blvd. Sunland, CA 91040 Office: 1638 Colorado Blvd #201, Los Angeles, CA 90041 Orange County Office: 23031 E. La Palma Ave. Yorba Linda, CA 92887 Alpha Structural, Inc. is a recognized leader in the engineering and construction of foundation, hillside repairs and soft story retrofitting. Having built many custom hillside homes in the 1980s, David Tourjé, the Owner and Chief Executive Officer of the company, decided to specialize in foundation and hillside repairs due to the increasing ...The Structural Assessor in Alpha Structural, Inc. is the one that will assess the property and recommend any repairs needed. Here at Alpha the Structural Assessor is senior to our engineering department in that they are the one to assess a property, design the solution and work out the proper budget for that repair. Alpha Structural completed a foundation and waterproofing job on my home in 2019. The cost of the job was over $20,000. Last month my home sustained over $15,000 worth of interior damage due to ... ALPHA-SYNUCLEIN STRUCTURE. α-Syn is a small acidic protein with three domains namely N-terminal lipid-binding α-helix, amyloid-binding central domain (NAC), and C-terminal acidic tail. α-Syn can be present as an α-helix structure in association with phospholipids or an unfolded conformation in the cytosol, suggesting that it plays specific roles … Alpha Structural specializes in the planning and construction of hillside ADU foundations across Los Angeles! So, if you are looking for an experienced and reputed contractor to build a stable and secure foundation system into your hillside, then contact us at (323) 258-5482 to schedule an inspection or request an estimate. You can also visit ... Alpha-keratin, or α-keratin, is a type of keratin found in mammalian vertebrates.This protein is the primary component in hairs, horns, claws, nails and the epidermis layer of the skin. α-keratin is a fibrous structural protein, meaning it is made up of amino acids that form a repeating secondary structure. The secondary structure of α-keratin is very similar to that of a … Alpha Structural, Inc. Headquarters: 8334 Foothill Blvd. Sunland, CA 91040 Office: 1638 Colorado Blvd #201, Los Angeles, CA 90041 Orange County Office: 23031 E. La Palma Ave. Yorba Linda, CA 92887 Alpha Engineering was established in 2007, and continues to provide engineering consulting for construction projects throughout Northern Ontario and Alberta. Based out of Thunder Bay, Ontario, Alpha specializes in structural engineering and project management. Speak with Alpha Engineering before starting your new build or …Alpha Structural, Inc. Headquarters: 8334 Foothill Blvd. Sunland, CA 91040 Office: 1638 Colorado Blvd #201, Los Angeles, CA 90041 Orange County Office: 23031 E. La Palma Ave. Yorba Linda, CA 92887Alpha Structural, Inc. Headquarters: 8334 Foothill Blvd. Sunland, CA 91040 Office: 1638 Colorado Blvd #201, Los Angeles, CA 90041 Orange County Office: 23031 E. La Palma Ave. Yorba Linda, CA 92887Schedule an engineering inspection to troubleshoot the issue. If your structure has cracked walls or a sagging roof, call on a highly trained structural engineer at Alpha Omega to check it out. We’ll respond quickly to evaluate the structural integrity of your home. During our engineering inspection, we’ll look at every part of your ...
Alpha Structural, Inc. is a leader in the field of balcony repairs. With over 25 years of experience, we have been supporting property owners with repairing and improving their structural needs and bringing their buildings up to par with today’s strict building codes. Alpha Structural is considered among the best companies at balcony repairs ... . Bcbs south carolina
The engineers at Alpha Structural can customize a drainage system to the layout of your home, guiding water away from the home and to the street via underground drain lines, concrete “swales”, landscape elevation grading etc. Not only is this a practical and cost-effective deterrent against water damage, it bolsters your home against the ... Who is Alpha Structural. Alpha Structural offers design and build structural repair services. It specializes in foundation repairs, structural repairs & upgrades, hillside repairs & earthquake retrofitting. The company was founded in 1993 and is based in Los Angeles, California. Read more. Alpha Structural's Social Media Facebook. 4.7 stars from 14 reviews. “Alpha Structural, Inc. Thanks for being the best construction team around! Even Megatron can’t break through my wall! Autobots Roll Out!!!”. Tom DeSanto. (Producer on Transformers Dark of the Moon) “Alpha Structural was an answer to our prayers. Specialties: Providing structural and geotechnical repairs and upgrades with our signature design/build approach for over 30 years. We service single-family, multi-family, industrial and commercial properties. Established in 1988. * #1,758 on 2019 Inc. 5000 list * #29 Fastest Growing Private Company in L.A. - L.A. Business Journal * Angie's List Super Service Award (2009 …Out with our Alpha Structural, Inc. #orangecounty team setting steel through the roof in Lake Forest. #crane #structuralsteel #steelconstruction… Liked by Nick Kurtz Alpha Structural, Inc. is a recognized leader in the engineering and construction of foundation, hillside repairs and soft story retrofitting. Having built many custom hillside homes in the 1980s, David Tourjé, the Owner and Chief Executive Officer of the company, decided to specialize in foundation and hillside repairs due to the increasing ... Alpha Structural's structural accessor shows the level of degradation to this homes foundation. Needless to say, this home is in dire need of a foundation repair. Call us today to schedule an inspection or request an estimate (323) 258-5482Nov 17, 2021 · The AlphaFold Protein Structure Database (AlphaFold DB, https://alphafold.ebi.ac.uk) is an openly accessible, extensive database of high-accuracy protein-structure predictions. Powered by AlphaFold v2.0 of DeepMind, it has enabled an unprecedented expansion of the structural coverage of the known … Alpha Structural, Inc. Headquarters: 8334 Foothill Blvd. Sunland, CA 91040 Office: 1638 Colorado Blvd #201, Los Angeles, CA 90041 Orange County Office: 23031 E. La Palma Ave. Yorba Linda, CA 92887 Alpha Structural, Inc. is a recognized leader in the engineering and construction of foundation repairs and hillside repairs. We're the ONLY Los Angeles foundation repair company licensed to ENGINEER and BUILD any type of repair project. We're up-front and honest. We won't try and sell you work you don't need, just what needs to be done. Alpha Structural, Inc. is the only foundation repair company in Los Angeles that is licensed to perform both the engineering and construction work for any type of repair project. With over 3 centuries of combined technical experience and some of the most experienced engineers in Southern California, we have solidified our reputation as an industry leader in hillside …Alpha Structural has been helping commercial property owners with a wide range of commercial services for more than two decades now – we are committed to delivering 100% quality work for all our clients. (323) 258-5482 Menu. Serving Los Angeles and Southern California for ...Any concrete tilt-up property built prior to 1976 is prone to significant damage during a major or even a moderate earthquake. This has resulted in mandatory ordinances, requiring such properties to receive a seismic retrofit in Los Angeles. A tilt-up building often contains a roof composed of light plywood connected to the concrete walls.In non-muscle cells, alpha-actinin is found along the actin filaments and in adhesion sites. In striated, cardiac and smooth muscle cells, it is localized at the Z-disk and analogous dense bodies, where it forms a lattice-like structure and stabilizes the muscle contractile apparatus. Besides binding to actin filaments alpha-actinin …Find company research, competitor information, contact details & financial data for ALPHA STRUCTURAL, INC. of Sunland, CA. Get the latest business insights from Dun & Bradstreet.a, Added structural coverage (per-protein, left; per-residue, middle) and per-residue confidence of regions not covered by SMR (right) for 11 species included in both the AF2 and SMR databases.b ...Call us today to schedule an inspection or request an estimate. (323) 258-5482. Request an Assessment or Estimate ». Alpha Structural, Inc. is a licensed, bonded and insured company. The #1 foundation repair contractor in Los Angeles. Foundation repair, foundation inspection. Alpha Structural, Inc. is a recognized leader in the engineering and construction of foundation repairs and hillside repairs. We're the ONLY Los Angeles foundation repair company licensed to ENGINEER and BUILD any type of repair project. We're up-front and honest. We won't try and sell you work you don't need, just what needs to be done. Nov 17, 2021 · The AlphaFold Protein Structure Database (AlphaFold DB, https://alphafold.ebi.ac.uk) is an openly accessible, extensive database of high-accuracy protein-structure predictions. Powered by AlphaFold v2.0 of DeepMind, it has enabled an unprecedented expansion of the structural coverage of the known ….